I've done a couple extended trips, just me and my wife in our tandem Feathercraft. We paddled from Mulege to La Paz, and also Bahia de los Angeles to La Paz, and circumnavigated many of the islands. Those were probably the best trips of my life.
Don't try to rent a kayak and equipment down there, just buy everything in the US and resell it after your trip if necessary. You need lots of reliable water storage; we used MSR Dromedary bags and carried almost 20 gallons when full. You want to go from north to south because of the prevailing winds. I drove down, dropped my gear at the put in and then paid someone to watch my rig. You can use the bus to shuttle; one time I left my car at the beginning of the trip, and once at a midpoint so I could resupply easily.
You'll want to find this book, which looks like it is out of print now. It's the only true guidebook I know of: https://www.amazon.com/Guide-Baja-Ka.../dp/0964539918
Bring fishing and snorkeling gear, and a wetsuit. I did well with a fishing spear which was fun. My trips were in March/April/May, but I hear November is really good also. Summer is way too hot, and winter too windy. You'll see whales, whale sharks, jumping rays, dolphins, amazing bird life... Great camping.
I think it's mostly safe, just know what you're doing and watch the wind- it can come up quick. We brought a sail which was really nice in the right conditions. You are really out there though, and sketchy people are always a possibility. One night we were asleep on a remote beach and our tent was spotlit by some fisherman in a panga, who proceeded to land right next to us. I got up and talked to them and they were nice guys who just slept for a few hours and were gone at 4am the next morning, but having four strangers show up like that and sleep next to the wife and me out there was... disconcerting.
If I could be out there again right now I would!