I'm from Kentucky, more hot women than anywhere in the lower 48. Maybe its inbreeding, or the water. Anyway...
Danville is boring (for boating, although Centre College has some hotties), but if you like creeks check out Madison County (Richmond), a bit east of where you'll be. Still exploring to do out there for some 1st D's.
Dix is flat, but good fishing.
Big South Fork was mentioned (world class class II-IV), the Upper Red River in the Red River Gorge is a beautiful class III run.
New and Clear Fork in Tennessee are nice, they form the Big South Fork just south of the KY border. You won't be disappointed in the RRG or the BSF.
Elkhorn Creek in Franklin County is a great class III run, and Benson Creek can be fun after a good rain. Both close to Danville.
Russell Fork and lots of other Appalachian runs 3-4 hours east of Danville.
For nightlife hit Lexington or Louisville. Or Richmond if you just need to get laid. Glad to give you more info, let me know. Beautiful country, and the people are genuinly very friendly. Not all, but most. Like everywhere else I suppose. I have good friends in Richmond, Lexington and Frankfort, they don't boat but they can show you a good time if you need a tour.
Couple of sites to check out...
Get this guide...5th edition is the latest I think...