I'm in agreement with others that flows in the teens cause the most problems. I have run the canyon at flows up to 24k and at 15k I found it especially challenging and scary. The holes in the drops become exploding breakers. The flow has jumped today from the upper 9ks to 10800, so mid or upper teens are likely. When does it wash out? It becomes different with each 1000 increase, but for me above 17k was "easier", but still a beast.
Wear a helmet. If the boat goes over the frame and gear can whack you hard.
Some folks use flip lines on the sides of their boats and others tie webbing from bow to stern or perpendicular across the bottom at the mid point. Much easier to get back on the boat, especially in huge turbulence.
I'm in agreement with the downstream ferry angle and right to left at Skull. I try to kiss the bottom of the lateral with the back right part of the boat (so, your upstream side tube). That way you will get spun towards the left side, then pull left more to miss the massive hole. If you hit the lateral in the center with the intent on punching through it you won't; as stated before it will catapult you into the hole.
The other significant drop is Funnel Falls. In the teens it has a right to left curler wave referred to as the Five-O wave. Think of a wave break in the ocean. Do not let this wave hit you from the side, as it will likely roll you. Be ready to spin the bow of your boat into the curler so that the boat slides on the long axis and not the short side-to-side.
Finally, I suggest no drinking or "smoking" until after Last Chance, at which time you will deserve it! Cheers and have a good run.