I paddled it a few years ago. Plan on getting on the river early to beat the headwinds and be off water by 1-2. Mexican side is where it is at for most camps. I didn't see much of anyone other than two groups b/c of spring break; one was from Texas Tech and the other from Ohio I think (can't remember). We paddled OC-1s but OC-2s work just as well. You will be spending a lot of time hugging the cane to stay out of the wind but if you get to camp early it is a lot more fun to watch the cliff swallows play in it. We did a low water run which was real nice actually - the water was often clear and a lot of it was from spring runoff. There was fresh water on river - read the Aulbach book. When the water is low - swimming is kinda nice at times - never expected to see the rio crystal clear but it happens.
I highly recommend ('Talkn') Ted Thayer for shuttle (He lives in the old RXR station in Marathon) - best to pick him up and have him drop you off in Blackgap (or wherever you choose to putin) - cheaper that way. Oh - there were two kids that blazed by us at the warm springs - they had two five gallon buckets tied to an OC2 w/ a bunch of beer in the bottom - they missed the takeout Dryden and wound up in Langtry. I saw them at takeout - Ted helped them out and he was waiting for us exactly when we told him we would be there. I asked him not to bother but he insisted for some reason - goofy guy - funny stories and entertaining ride...
There be some Mt Lyons down there - you will see fresh scat - they will watch you but doubt you will see them
but their dens are easy enough to find.
Do not bring inflatable unless there is a lot of water
I am not sure about safety atm - it can be kinda sketchy down here but most of the problems are around Del Rio. There were some problems around Falcon lake but anything going on around the lower canyons - they don't want to draw attention to. You will check in at Panther Junction - they will give you a customs form to fill out and mail in when you are done. You are allowed to go on the Mexican side but not to 'populated places' (don't ask - doesn't make any sense to me either). But, check Boquias b4 u go and have a new passport - they are opening the crossing up again w/ a camera to another location and you con go get a cerveza
Good luck - I loved that trip - I may never do it again but another trip worth looking into is the Pecos; there are even less people there - like no-one - ever