Below 500 is a wide range of difficulty throughout the run. My general rule is as follows (kinda, this is at least close).
less than 130, not reccomeneded
130-330 Run the bottom 4 only (put in at Brains). Kiss Me is the most likely portage. (V- below 250ish, V to V+ above)
330-450 The bottom 4 are getting really big at places, but the inbetween is great. The top (above Brains) is a little low, but it offers a good warmup to the big stuff.
450 and up. I only plan on running the top (NIMBY and others are fun, watch for wood), and then pick apart the bottom if I feel good. Cauldron is going to be very juicy.
I usually only put-in about a mile above NIMBY, at a large dirt turnout on the left. I know this skips some stuff up top, but its a long run regardless, and I mostly paddled it after work.
I portage Kiss Me often. I've only run it two or three times out of 20+ trips. It's ugly. This is the drop immediately below Paralyzer, with one eddy between the two.
Not going to make it up there this weekend, going to take it easy. Have fun!