I live next to Cherry Creek and look at it all the time. There is some appeal in running stuff that almost never runs, but Cherry Creek just isn't worth it. Note that even jonny water says he doesn't recommend it after his run. There aren't many drops and the low bridges with railings scare me. Those railings can kill a boater if you can't eddy out.
The biggest appeal to running Cherry Creek is going through the exclusive Cherry Creek Country Club and getting weird looks from people on the bike path.
But, when Cherry Creek is running, there is probably great boating at Union Chutes and the Tressle Wave below Confluence, like yesterday. It's just not worth it.