You will want Little River at 2500+cfs to run the center line at the falls. HOWEVER, I would caution that although it looks fairly simple, that is actually a difficult class V drop with a very hard lip and a very green landing. It would be easy to break your back there if you landed wrong.
I would recommend hitting Rock Island and working some of the lines over Great Falls there before attempting higher/harder drops. The sedimentary rock on the plateau makes for a lot of waterfalls, but it also makes for a lot of hard lips.
In general, the whitewater in the area you are moving to will be less continuous and more dangerous (sieves, undercuts) than what you are used to in Colorado. Whitewater here requires more careful consideration/line planning and less seat-of-your-pants reaction than paddling in the Rockies does.
Your best bet for catching whitewater between Colorado and the SE is the St. Francis in Missouri. It's right at the low end level right now, but a little rain could get it going depending on your timing.
The Little River Canyon, Rock Island, and the St. Francis are all in my North America guidebook, which is linked in my sig at the bottom of this post.
We also have a rive gauge page that has all of those included so you can go to one place and see which ones are running:
River Gypsies' Flows Page
Welcome to the Southeast!